Stimulation of Osteoblastic Cell Differentiation by Notch
نویسندگان
چکیده
منابع مشابه
Stimulation of human epidermal differentiation by Delta–Notch signalling at the boundaries of stem-cell clusters
BACKGROUND Human epidermis is renewed throughout life from stem cells in the basal layer of the epidermis. Signals from the surrounding keratinocytes influence the differentiation of the stem cells, but the nature of the signals is unknown. In many developing tissues, signalling mediated by the transmembrane protein Delta1 and its receptor Notch1 inhibits differentiation. Here, we investigated ...
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The Notch pathway is involved in determining cell fate within the nervous system and in various sensory organs (Lanford et al., 1999; Cau et al., 2000; Furukawa et al., 2000; Ito et al., 2000; Zine et al., 2000). For example, Mash1 is expressed in subsets of neuronal precursors in both the central nervous system (CNS) and the peripheral nervous system (PNS) (Guillemot et al., 1993). Disruption ...
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Coordinating exit from the cell cycle with differentiation is crucial for proper development and tissue homeostasis. Failure to do so can lead to aberrant organogenesis and tumorigenesis. However, little is known about the developmental signals that regulate the switch from cell cycle exit to differentiation. Signals downstream of two key developmental pathways, Notch and Salvador-Warts-Hippo (...
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Embryonic stem (ES) cells display heterogeneous responses upon induction of differentiation. Recent analysis has shown that Hes1 expression oscillates with a period of about 3-5 h in mouse ES cells and that this oscillating expression contributes to the heterogeneous responses: Hes1-high ES cells are prone to the mesodermal fate, while Hes1-low ES cells are prone to the neural fate. These outco...
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Estrogen (E2) has been shown to prevent bone loss among postmenopausal women. The molecular mechanism(s) by which this is accomplished is not clear. The discovery of E2 receptor (ER) in osteoblasts and osteoclasts has implicated these cells as direct targets for E2. Previous studies on the effects of E2 on osteoblastic cells in vitro or in organ culture present conflicting results, possibly due...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2002
ISSN: 0884-0431
DOI: 10.1359/jbmr.2002.17.2.231